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Previous preclinical studies showed that in paclitaxel-induced CIPN models, oral melatonin pretreatment significantly reduced paclitaxel-induced mechanical allergic reactions in male and female animals by decreasing paclitaxel-induced 8-isoprostane F2 levels and C-fiber activity-dependent slowing (ADS) in peripheral nerves, and importantly, melatonin cotreatment with breast or ovarian cancer cells alleviated mitochondrial damage without affecting paclitaxel cytotoxicity [44]